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[数据库推荐经典文章]

Luminal signalling links cell communication to tissue architecture during organogenesis.

2014.11.12
  Nature. 2014 Nov 6; 515(7525):120-4  
     
[数据库推荐经典文章]

A molecular ruler determines the repeat length in eukaryotic cilia and flagella.

2014.11.12
  Science. 2014 Nov 14; 346(6211):857-60  
     
[数据库推荐经典文章]

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer.

2014.11.12
  Nature. 2014 Nov 27; 515(7528):558-62  
     
[数据库推荐经典文章]

Glycemic control and excess mortality in type 1 diabetes.

2014.11.12
  N Engl J Med. 2014 Nov 20; 371(21):1972-82  
     
[数据库推荐经典文章]

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

2014.11.12
  Nature. 2014 Nov 20; 515(7527):431-5  
     
[数据库推荐经典文章]

Life cycles, fitness decoupling and the evolution of multicellularity.

2014.11.12
  Nature. 2014 Nov 6; 515(7525):75-9  
     
[数据库推荐经典文章]

Structure of the large ribosomal subunit from human mitochondria.

2014.11.12
  Science. 2014 Nov 7; 346(6210):718-22  
     
[数据库推荐经典文章]

Spatial map of human T cell compartmentalization and maintenance over decades of life.

2014.11.12
  Cell. 2014 Nov 6; 159(4):814-28  
     
[数据库推荐经典文章]

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling.

2014.11.12
  Science. 2014 Nov 7; 346(6210):1257521  
     
[数据库推荐经典文章]

Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells.

2014.11.12
  Nat Cell Biol. 2014 Nov; 16(11):1045-56  
     
[数据库推荐经典文章]

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.

2014.10.11
  Cell. 2014 Oct 9; 159(2):440-55  
     
[数据库推荐经典文章]

T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses.

2014.10.11
  Science. 2014 Oct 3; 346(6205):98-101  
     
[数据库推荐经典文章]

Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics.

2014.10.11
  Nat Genet. 2014 Oct; 46(10):1072-80  
     
[数据库推荐经典文章]

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors.

2014.10.11
  Nature. 2014 Oct 15  
     
[数据库推荐经典文章]

Artificial sweeteners induce glucose intolerance by altering the gut microbiota.

2014.10.11
  Nature. 2014 Oct 9; 514(7521):181-6  
     
[数据库推荐经典文章]

Structural basis for organohalide respiration.

2014.10.11
  Nature. 2014 Oct 30; 514(7524):585-90  
     
[数据库推荐经典文章]

Mesenchymal-endothelial transition contributes to cardiac neovascularization.

2014.10.11
  Nature. 2014 Oct 30; 514(7524):585-90  
     
[数据库推荐经典文章]

Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus.

2014.10.11
  Science. 2014 Oct 31; 346(6209):641-6  
     
[数据库推荐经典文章]

Membrane trafficking. The specificity of vesicle traffic to the Golgi is encoded in the golgin coiled-coil proteins.

2014.10.11
  Science. 2014 Oct 31; 346(6209):1256898  
     
[数据库推荐经典文章]

Crystal structure and mechanistic investigation of the twister ribozyme.

2014.9.5
  Nat Chem Biol. 2014 Sep; 10(9):739-44  
     
[数据库推荐经典文章]

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.

2014.9.5
  Nat Med. 2014 Sep; 20(9):1043-9  
     
[数据库推荐经典文章]

An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.

2014.9.5
  Nat Cell Biol. 2014 Sep; 16(9):909-17  
     
[数据库推荐经典文章]

Eosinophilic Esophagitis in Adults Is Associated With IgG4 and Not Mediated by IgE.

2014.9.5
  Gastroenterology. 2014 Sep; 147(3):602-9  
     
[数据库推荐经典文章]

A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.

2014.9.5
  Cell. 2014 Sep 11; 158(6):1402-14  
     
[数据库推荐经典文章]

Developmental plasticity and the origin of tetrapods.

2014.9.5
  Nature. 2014 Sep 4; 513(7516):54-8  
     
[数据库推荐经典文章]

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits.

2014.9.5
  Neuron. 2014 Sep 3; 83(5):1131-43  
     
[数据库推荐经典文章]

Molecular architecture and mechanism of the anaphase-promoting complex.

2014.9.5
  Nature. 2014 Sep 18; 513(7518):388-93  
     
[数据库推荐经典文章]

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak.

2014.9.5
  Science. 2014 Sep 12; 345(6202):1369-72  
     
[数据库推荐经典文章]

A critical time window for dopamine actions on the structural plasticity of dendritic spines.

2014.9.5
  Science. 2014 Sep 26; 345(6204):1616-20  
     
[数据库推荐经典文章]

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity.

2014.8.13
  J Clin Invest. 2014 Aug 1; 124(8):3391-406  
     
[数据库推荐经典文章]

Endostatin is a trans-synaptic signal for homeostatic synaptic plasticity.

2014.8.13
  Neuron. 2014 Aug 6; 83(3):616-29  
     
[数据库推荐经典文章]

Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms.

2014.8.13
  Nature. 2014 Aug 7; 512(7512):78-81  
     
[数据库推荐经典文章]

Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys.

2014.8.13
  Nature. 2014 Aug 7; 512(7512):74-7  
     
[数据库推荐经典文章]

Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.

2014.8.13
  Science. 2014 Aug 8; 345(6197):688-93  
     
[数据库推荐经典文章]

Crystal structure of the human COP9 signalosome.

2014.8.13
  Nature. 2014 Aug 14; 512(7513):161-5  
     
[数据库推荐经典文章]

Synthesis and folding of a mirror-image enzyme reveals ambidextrous chaperone activity.

2014.8.13
  Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):116  
     
[数据库推荐经典文章]

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix.

2014.8.13
  Science. 2014 Aug 29; 345(6200):1062-5  
     
[数据库推荐经典文章]

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.

2014.8.13
  Cell. 2014 Aug 28; 158(5):1110-22  
     
[数据库推荐经典文章]

Immunogenetics. Chromatin state dynamics during blood formation.

2014.8.13
  Science. 2014 Aug 22; 345(6199):943-9  
     
[数据库推荐经典文章]

Comparative phylogenomics uncovers the impact of symbiotic associations on host genome evolution.

2014.7.14
  PLoS Genet. 2014 Jul; 10(7):e1004487  
     
[数据库推荐经典文章]

Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8⁺ Central Memory T Cells.

2014.7.14
  Immunity. 2014 Jul; 41(1):116-26  
     
[数据库推荐经典文章]

Linking T-cell receptor sequence to functional phenotype at the single-cell level.

2014.7.14
  Nat Biotechnol. 2014 Jul; 32(7):684-92  
     
[数据库推荐经典文章]

Horizontal genome transfer as an asexual path to the formation of new species.

2014.7.14
  Nature. 2014 Jul 10; 511(7508):232-5  
     
[数据库推荐经典文章]

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.

2014.7.14
  Cell. 2014 Jul 3; 158(1):157-70  
     
[数据库推荐经典文章]

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk.

2014.7.14
  Nature. 2014 Jul 3; 511(7507):99-103  
     
[数据库推荐经典文章]

Structural basis for lipopolysaccharide insertion in the bacterial outer membrane.

2014.7.14
  Nature. 2014 Jul 3; 511(7507):108-11  
     
[数据库推荐经典文章]

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development.

2014.7.14
  Cell. 2014 Jul 17; 158(2):263-76  
     
[数据库推荐经典文章]

APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly.

2014.7.14
  Cell. 2014 Jul 17; 158(2):368-82  
     
[数据库推荐经典文章]

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair.

2014.7.14
  Cell. 2014 Jul 17; 158(2):327-38  
     
[数据库推荐经典文章]

Olfactory exposure to males, including men, causes stress and related analgesia in rodents.

2014.6.10
  Nat Methods. 2014 Jun; 11(6):629-32  
     
[数据库推荐经典文章]

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

2014.6.10
  Nat Med. 2014 Jun; 20(6):659-663  
     
[数据库推荐经典文章]

Lung microbiota promotes tolerance to allergens in neonates via PD-L1.

2014.6.10
  Nat Med. 2014 Jun; 20(6):642-7  
     
[数据库推荐经典文章]

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.

2014.6.10
  Nat Cell Biol. 2014 Jun; 16(6):561-73  
     
[数据库推荐经典文章]

Three-dimensional structure of human γ-secretase.

2014.6.10
  Nature. 2014 Jun 29  
     
[数据库推荐经典文章]

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.

2014.6.10
  Science. 2014 Jun 6; 344(6188):1164-8  
     
[数据库推荐经典文章]

Emergence of reproducible spatiotemporal activity during motor learning.

2014.6.10
  Nature. 2014 Jun 12; 510(7504):263-7  
     
[数据库推荐经典文章]

Crystal cryocooling distorts conformational heterogeneity in a model michaelis complex of DHFR.

2014.6.10
  Structure. 2014 Jun 10; 22(6):899-910  
     
[数据库推荐经典文章]

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance.

2014.6.10
  Nature. 2014 Jun 26; 510(7506):503-6  
     
[数据库推荐经典文章]

Activated T Cells Secrete an Alternatively Spliced Form of Common γ-Chain that Inhibits Cytokine Signaling and Exacerbates Inflammation.

2014.6.10
  Immunity. 2014 Jun 19; 40(6):910-23  
     
[数据库推荐经典文章]

A randomized trial of protocol-based care for early septic shock.

2014.5.17
  N Engl J Med. 2014 May 1; 370(18):1683-93  
     
[数据库推荐经典文章]

Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants.

2014.5.17
  Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):649  
     
[数据库推荐经典文章]

Broad-spectrum anti-biofilm peptide that targets a cellular stress response.

2014.5.17
  PLoS Pathog. 2014 May; 10(5):e1004152  
     
[数据库推荐经典文章]

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines.

2014.5.17
  Nat Med. 2014 May; 20(5):511-7  
     
[数据库推荐经典文章]

Gibberellin acts positively then negatively to control onset of flower formation in Arabidopsis.

2014.5.17
  Science. 2014 May 9; 344(6184):638-41  
     
[数据库推荐经典文章]

Hippocampal neurogenesis regulates forgetting during adulthood and infancy.

2014.5.17
  Science. 2014 May 9; 344(6184):598-602  
     
[数据库推荐经典文章]

Structure of the AcrAB-TolC multidrug efflux pump.

2014.5.17
  Nature. 2014 May 22; 509(7501):512-5  
     
[数据库推荐经典文章]

Protective mucosal immunity mediated by epithelial CD1d and IL-10.

2014.5.17
  Nature. 2014 May 22; 509(7501):497-502  
     
[数据库推荐经典文章]

A semi-synthetic organism with an expanded genetic alphabet.

2014.5.17
  Nature. 2014 May 15; 509(7500):385-8  
     
[数据库推荐经典文章]

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation.

2014.5.17
  elife. 2014 May 29:e02872  
     
[数据库推荐经典文章]

Structure of a type IV secretion system.

2014.4.16
  Nature. 2014 Apr 24; 508(7497):550-3  
     
[数据库推荐经典文章]

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells.

2014.4.16
  Cell. 2014 Apr 24; 157(3):580-94  
     
[数据库推荐经典文章]

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus.

2014.4.16
  Nat Cell Biol. 2014 Apr; 16(4):376-81  
     
[数据库推荐经典文章]

Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking.

2014.4.16
  Nat Neurosci. 2014 Apr; 17(4):577-85  
     
[数据库推荐经典文章]

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

2014.4.16
  Nature. 2014 Apr 10; 508(7495):222-7  
     
[数据库推荐经典文章]

A controlled trial of renal denervation for resistant hypertension.

2014.4.16
  N Engl J Med. 2014 Apr 10; 370(15):1393-401  
     
[数据库推荐经典文章]

Aspirin in patients undergoing noncardiac surgery.

2014.4.16
  N Engl J Med. 2014 Apr 17; 370(16):1494-503  
     
[数据库推荐经典文章]

Rescuing US biomedical research from its systemic flaws.

2014.4.16
  Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):577  
     
[数据库推荐经典文章]

Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.

2014.4.16
  Cell. 2014 Apr 24; 157(3):549-64  
     
[数据库推荐经典文章]

Olfactory exposure to males, including men, causes stress and related analgesia in rodents.

2014.4.16
  Nat Methods. 2014 Apr 28  
     
[数据库推荐经典文章]

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.

2014.3.5
  Nature. 2014 Mar 20; 507(7492):366-70  
     
[数据库推荐经典文章]

Obesity-associated variants within FTO form long-range functional connections with IRX3.

2014.3.5
  Nature. 2014 Mar 20; 507(7492):371-5  
     
[数据库推荐经典文章]

A Randomized Trial of Protocol-Based Care for Early Septic Shock.

2014.3.5
  N Engl J Med. 2014 Mar 18  
     
[数据库推荐经典文章]

REST and stress resistance in ageing and Alzheimer disease.

2014.3.5
  Nature. 2014 Mar 27; 507(7493):448-54  
     
[数据库推荐经典文章]

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.

2014.3.5
  Science. 2014 Mar 28; 343(6178):1249288  
     
[数据库推荐经典文章]

Structure of the yeast mitochondrial large ribosomal subunit.

2014.3.5
  Science. 2014 Mar 28; 343(6178):1485-9  
     
[数据库推荐经典文章]

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone.

2014.3.5
  Nature. 2014 Mar 20; 507(7492):323-8  
     
[数据库推荐经典文章]

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.

2014.3.5
  Nature. 2014 Mar 6; 507(7490):118-23  
     
[数据库推荐经典文章]

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.

2014.3.5
  Nature. 2014 Mar 6; 507(7490):109-13  
     
[数据库推荐经典文章]

Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes.

2014.3.5
  Anesthesiology. 2014 Mar; 120(3):564-78  
     
[数据库推荐经典文章]

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis.

2014.2.15
  Nat Med. 2014 Feb; 20(2):159-66  
     
[数据库推荐经典文章]

HIV-1 persistence in CD4+ T cells with stem cell-like properties.

2014.2.15
  Nat Med. 2014 Feb; 20(2):139-42  
     
[数据库推荐经典文章]

Crystalloid or colloid for goal-directed fluid therapy in colorectal surgery.

2014.2.15
  Br J Anaesth. 2014 Feb; 112(2):281-9  
     
[数据库推荐经典文章]

Molecular control of δ-opioid receptor signalling.

2014.2.15
  Nature. 2014 Feb 13; 506(7487):191-6  
     
[数据库推荐经典文章]

Scientific method: statistical errors.

2014.2.15
  Nature. 2014 Feb 13; 506(7487):150-2  
     
[数据库推荐经典文章]

RNA viruses can hijack vertebrate microRNAs to suppress innate immunity.

2014.2.15
  Nature. 2014 Feb 13; 506(7487):245-8  
     
[数据库推荐经典文章]

Dendritic inhibition in the hippocampus supports fear learning.

2014.2.15
  Science. 2014 Feb 21; 343(6173):857-63  
     
[数据库推荐经典文章]

Neurogenesis in the striatum of the adult human brain.

2014.2.15
  Cell. 2014 Feb 27; 156(5):1072-83  
     
[数据库推荐经典文章]

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.

2014.2.15
  Nature. 2014 Feb 27; 506(7489):503-6  
     
[数据库推荐经典文章]

Cell surface ABP1-TMK auxin-sensing complex activates ROP GTPase signaling.

2014.2.15
  Science. 2014 Feb 28; 343(6174):1025-8  
     
[数据库推荐经典文章]

Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity.

2014.1.15
  Science. 2014 Jan 24; 343(6169):432-7  
     
[数据库推荐经典文章]

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids.

2014.1.15
  Nature. 2014 Jan 9; 505(7482):218-22  
     
[数据库推荐经典文章]

HMGA2 functions as a competing endogenous RNA to promote lung cancer progression.

2014.1.15
  Nature. 2014 Jan 9; 505(7482):212-7  
     
[数据库推荐经典文章]

Patterning and growth control by membrane-tethered Wingless.

2014.1.15
  Nature. 2014 Jan 9; 505(7482):180-5  
     
[数据库推荐经典文章]

Association of the autoimmune disease scleroderma with an immunologic response to cancer.

2014.1.15
  Science. 2014 Jan 10; 343(6167):152-7  
     
[数据库推荐经典文章]

Genome-scale CRISPR-Cas9 knockout screening in human cells.

2014.1.15
  Science. 2014 Jan 3; 343(6166):84-7  
     
[数据库推荐经典文章]

Genetic screens in human cells using the CRISPR-Cas9 system.

2014.1.15
  Science. 2014 Jan 3; 343(6166):80-4  
     
[数据库推荐经典文章]

Stenting and medical therapy for atherosclerotic renal-artery stenosis.

2014.1.15
  N Engl J Med. 2014 Jan 2; 370(1):13-22  
     
[数据库推荐经典文章]

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel.

2014.1.15
  Nature. 2014 Jan 2; 505(7481):56-61  
     
[数据库推荐经典文章]

A widespread self-cleaving ribozyme class is revealed by bioinformatics.

2014.1.15
  Nat Chem Biol. 2014 Jan; 10(1):56-60  
     
[数据库推荐经典文章]

Ultrafast endocytosis at mouse hippocampal synapses.

2013.12.13
  Nature. 2013 Dec 4  
     
[数据库推荐经典文章]

Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags.

2013.12.13
  Nat Med. 2013 Dec; 19(12):1661-6  
     
[数据库推荐经典文章]

Adductor Canal Block Versus Femoral Nerve Block for Analgesia After Total Knee Arthroplasty: A Randomized, Double-blind Study.

2013.12.13
  Reg Anesth Pain Med. 2013 Nov-Dec; 38(6):526-32  
     
[数据库推荐经典文章]

5 year efficacy of a bivalent killed whole-cell oral cholera vaccine in Kolkata, India: a cluster-randomised, double-blind, placebo-controlled trial.

2013.12.13
  Lancet Infect Dis. 2013 Dec; 13(12):1050-6  
     
[数据库推荐经典文章]

Sexual behaviour of heterosexual men and women receiving antiretroviral pre-exposure prophylaxis for HIV prevention: a longitudinal analysis.

2013.12.13
  Lancet Infect Dis. 2013 Dec; 13(12):1021-8  
     
[数据库推荐经典文章]

Structure of the TRPV1 ion channel determined by electron cryo-microscopy.

2013.12.13
  Nature. 2013 Dec 5; 504(7478):107-12  
     
[数据库推荐经典文章]

Targeted temperature management at 33°C versus 36°C after cardiac arrest.

2013.12.13
  N Engl J Med. 2013 Dec 5; 369(23):2197-206  
     
[数据库推荐经典文章]

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

2013.12.13
  Nat Genet. 2013 Dec; 45(12):1479-82  
     
[数据库推荐经典文章]

Long-distance integration of nuclear ERK signaling triggered by activation of a few dendritic spines.

2013.12.13
  Science. 2013 Nov 29; 342(6162):1107-11  
     
[数据库推荐经典文章]

The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria.

2013.12.13
  Science. 2013 Nov 29; 342(6162):1237435  
     
[数据库推荐经典文章]

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

2013.12.13
  Nature. 2013 Nov 28; 503(7477):530-4  
     
[数据库推荐经典文章]

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.

2013.12.13
  Nature. 2013 Nov 28; 503(7477):548-51  
     
[数据库推荐经典文章]

A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice.

2013.12.13
  Nat Commun. 2013 Nov 26; 4:2825  
     
[数据库推荐经典文章]

Revised standards for statistical evidence.

2013.12.13
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2013.12.13
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2013.10.17
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2013.9.16
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2013.9.16
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2013.9.16
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2013.8.15
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2012.10.29
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2012.10.29
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2012.10.29
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2012.10.29
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2012.10.29
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2012.8.20
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2012.8.20
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2012.8.20
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2012.8.20
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2012.8.20
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2012.8.20
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2012.8.20
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2012.6.1
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2012.6.1
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2012.6.1
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2012.6.1
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2012.6.1
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2012.6.1
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2012.4.28
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Structural basis of ultraviolet-B perception by UVR8.

2012.4.28
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2012.4.28
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2012.4.28
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2012.3.21
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2012.3.21
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2012.3.21
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2012.3.21
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2012.3.21
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2012.3.21
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2012.3.21
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2011.10.25
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2011.10.25
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2011.10.25
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2011.10.25
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2011.10.25
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2011.10.25
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2011.7.5
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2011.7.5
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Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG).

2011.7.5
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2011.7.5
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An algorithm for difficult airway management, modified for modern optical devices (Airtraq laryngoscope; LMA CTrach): a 2-year prospective validation in patients for elective abdominal, gynecologic, and thyroid surgery.

2011.5.5
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2011.5.5
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Addition of atrasentan to Renin-Angiotensin system blockade reduces albuminuria in diabetic nephropathy.

2011.5.5
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2011.5.5
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2011.5.5
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2011.5.5
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2010.10.29
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2010.10.29
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2010.10.29
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2010.10.29
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2010.8.25
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2010.8.25
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2010.8.25
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2010.8.25
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2010.8.25
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2010.6.25
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2010.6.25
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2010.6.25
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2010.6.25
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2010.6.25
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2010.5.17
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2010.5.17
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2010.5.17
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2010.5.17
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2010.5.17
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2010.5.17
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2010.5.17
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2010.5.17
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2010.5.17
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2010.5.17
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2010.5.17
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2010.5.17
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2010.3.15
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2010.3.15
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2010.3.15
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2010.3.15
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2010.3.15
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2010.3.15
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2010.3.15
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2010.3.15
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2010.3.15
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2010.3.15
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2010.1.21
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2010.1.21
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2010.1.21
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2010.1.21
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2010.1.21
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Predicting new molecular targets for known drugs.

2010.1.21
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Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.

2010.1.21
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X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.

2010.1.21
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Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.

2010.1.21
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Assembly of endogenous oskar mRNA particles for motor-dependent transport in the Drosophila oocyte.

2010.1.21
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Reactome array: forging a link between metabolome and genome.

2009.12.3
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Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis.

2009.12.3
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Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit.

2009.12.3
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Identification of residues on Hsp70 and Hsp90 ubiquitinated by the co-chaperone CHIP.

2009.12.3
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Generation of functional ventricular heart muscle from mouse ventricular progenitor cells.

2009.12.3
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Direct inhibition of the NOTCH transcription factor complex.

2009.12.3
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The Vam6 GEF controls TORC1 by activating the EGO complex.

2009.12.3
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C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).

2009.12.3
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Kinetic advantage of intrinsically disordered proteins in coupled folding-binding process: a critical assessment of the

2009.12.3
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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

2009.9.1
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Maturation of active zone assembly by Drosophila Bruchpilot

2009.9.1
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Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination

2009.9.1
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Architecture and secondary structure of an entire HIV-1 RNA genome

2009.9.1
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Developmental roles of 21 Drosophila transcription factors are determined by quantitative

2009.9.1
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Role of layer 6 of V2 visual cortex in object-recognition memory

2009.9.1
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Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA

2009.9.1
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Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity

2009.9.1
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Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut

2009.9.1
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Architecture and secondary structure of an entire HIV-1 RNA genome

2009.9.1
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Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity.

2009.7.2
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Functional expression of the olfactory signaling system in the kidney.

2009.7.2
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Jasmonic acid control of GLABRA3 links inducible defense and trichome patterning in

2009.7.2
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Functional expression of the olfactory signaling system in the kidney.

2009.7.2
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The fic domain: regulation of cell signaling by adenylylation.

2009.7.2
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Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model.

2009.7.2
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Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure.

2009.7.2
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Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis.

2009.7.2
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ChIP-seq accurately predicts tissue-specific activity of enhancers.

2009.7.2
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Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

2009.7.2
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Structural polymorphism of 441-residue tau at single residue resolution.

2009.5.31
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Paternal control of embryonic patterning in Arabidopsis thaliana

2009.5.31
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Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

2009.5.31
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Innate immunity and intestinal microbiota in the development of Type 1 diabetes.

2009.5.31
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Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection.

2009.5.31
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Species-specific transcription in mice carrying human chromosome 21.

2009.5.31
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Purification of proteins associated with specific genomic Loci.

2009.3.5
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A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types.

2009.3.5
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Deregulated expression of the plant glutamate receptor homolog AtGLR3.1 impairs long-term

2009.3.5
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Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity.

2009.3.5
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Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in

2009.3.5
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An Arabidopsis GPI-Anchor Plasmodesmal Neck Protein with Callose Binding Activity and

2009.3.5
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In vivo cloning of artificial DNA nanostructures.

2009.3.5
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Class 1 KNOX genes are not involved in shoot development in the moss Physcomitrella patens

2009.3.5
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Large-scale structural analysis of the classical human protein tyrosine phosphatome.

2009.3.5
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Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3

2009.3.5
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Structure and functional role of dyneins microtubule-binding domain

2009.1.20
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Functional Genetic Link between Distinct Developmental Language Disorders

2009.1.20
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Contact inhibition of locomotion in vivo controls neural crest directional migration.

2009.1.20
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Plant pattern-recognition receptor FLS2 is directed for degradation by the bacterial

2009.1.20
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Trans-specific gene silencing between host and parasitic plants.

2009.1.20
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Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who

2009.1.20
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Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell

2009.1.20
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Genomic anatomy of the hippocampus.

2009.1.20
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Astroglial metabolic networks sustain hippocampal synaptic transmission.

2009.1.20
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Contact inhibition of locomotion in vivo controls neural crest directional migration.

2009.1.20
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Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator.

2008.11.7
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Internally generated reactivation of single neurons in human hippocampus during free recall.

2008.11.7
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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.

2008.11.7
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Control of gene expression by a natural metabolite-responsive ribozyme

2008.11.7
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CTLA-4 control over Foxp3+ regulatory T cell function

2008.11.7
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Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.

2008.11.7
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Trex1 prevents cell-intrinsic initiation of autoimmunity.

2008.11.7
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Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization

2008.11.7
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In vivo reprogramming of adult pancreatic exocrine cells to b-cells

2008.11.7
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Structure of a complex of the ATPase SecA and the protein-translocation channel.

2008.11.7
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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.

2008.9.17
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Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway.

2008.9.17
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TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment.

2008.9.17
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Tolerance of NK cells encountering their viral ligand during development.

2008.9.17
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Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis.

2008.9.17
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Field experiments with transformed plants reveal the sense of floral scents.

2008.9.17
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Centrosome Dysfunction in Drosophila Neural Stem Cells Causes Tumors that Are Not due to Genome Instability.

2008.9.17
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A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators.

2008.9.17
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Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype.

2008.9.17
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Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair.

2008.9.17
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A New Tumor Suppressor Gene: Invasion, Metastasis, and Angiogenesis as Potential Key Targets

2008.6.24
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Linear Discriminant Analysis-Based Estimation of the False Discovery Rate for Phosphopeptide Identifications

2008.6.24
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Electricity Generation by Rhodopseudomonas palustris DX-1

2008.6.24
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E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer.

2008.4.18
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Indolizidine and quinolizidine alkaloids.

2008.4.17
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Small fitness effect of mutations in highly conserved non-coding regions

2008.4.17
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A Genome Scan to Detect Candidate Regions Influenced by Local Natural Selection in Human Populations

2008.4.17
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Identification of Candida albicans Genes that Induce Saccharomyces cerevisiae Cell Adhesion

2008.4.17
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A Proteome Resource of Ovarian Cancer Ascites: Integrated Proteomic and Bioinformatic

2008.4.17
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Temporal and parental-specific expression of imprinted genes in a newly derived Chinese human embryonic stem cell line and embryoid bodies.

2008.2.13
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Genetic Interactions Between Leaf Polarity-Controlling Genes and ASYMMETRIC LEAVES1 and 2 in Arabidopsis Leaf Patterning.

2008.2.13
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Purification, Refolding, Crystallization and Diffraction Analysis of the Native and Selenomethionine-Substituted Rat Epidymal-Specific Lipocalin.

2008.2.13
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Cellular targets of natural products.

2008.2.13
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Management of hepatitis B: Summary of a clinical research workshop

2008.2.13
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3D-QSAR CoMFA studies on trypsin-like serine protease inhibitors: a

2008.2.13
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Endogenous Arginine-Phenylalanine-Amide-related Peptides Alter

2008.2.13
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β Cells Can Be Generated from Endogenous Progenitors in Injured

2008.2.13
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Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model.

2008.1.3
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Noradrenaline Modulates Transmission at a Central Synapse by a Presynaptic Mechanism.

2008.1.3
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A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop.

2008.1.3
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors.

2008.1.3
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From inflammation to sickness and depression: when the immune system subjugates the brain.

2008.1.3
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Isolated CP1 domain of Escherichia coli leucyl-tRNA synthetase is dependent on flanking hinge motifs for amino acid editing activity.

2008.1.3
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Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells.

2008.1.3
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Pyruvate induces mitochondrial biogenesis by a PGC-1 {alpha}-independent mechanism.

2008.1.3
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Proteomic analysis of silk gland programmed cell death during metamorphosis of the silkworm Bombyx mori.

2008.1.3
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CCAAT/enhancer-binding protein (C/EBP) beta is acetylated at multiple lysines: acetylation of C/EBPbeta at lysine 39 modulates its ability to activate transcription.

2008.1.3
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New histone incorporation marks sites of UV repair in human cells.

2007.11.23
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Met5-enkephalin-induced cardioprotection occurs via transactivation of EGFR and activation of PI3K.

2007.11.23
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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.

2007.11.23
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2007.11.23
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Combination therapy with PPARgamma and PPARalpha agonists increases glucose-stimulated insulin secretion in db/db mice

2007.11.23
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2007.11.23
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2007.11.23
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C/EBPbeta reprograms white 3T3-L1 preadipocytes to a Brown adipocyte pattern of gene expression.

2007.11.23
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2007.11.23
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2007.11.23
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Chemokine CXCL12 Induces Binding of Ferritin Heavy Chain to the Chemokine Receptor CXCR4, Alters CXCR4 Signaling, and Induces Phosphorylation and Nuclear Translocation of Ferritin Heavy Chain.

2007.10.29
  J Biol Chem.2006;281(49):37616-27[JBC]  
     
[数据库推荐经典文章]

A model for random sampling and estimation of relative protein abundance in shotgun proteomics.

2007.10.29
  Anal Chem. 2004 ;76(14):4193-201.[ACS]  
     
[数据库推荐热点文章]

Domain 2 of Nonstructural Protein 5A (NS5A) of Hepatitis C Virus Is Natively Unfolded.

2007.10.29
  Biochemistry. 2007;46(41):11550-8.[ACS]  
     
[数据库推荐热点文章]

Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2

2007.10.18
  Cell, V.129(2),2007, P303-317[Cell Press]  
     
[数据库推荐热点文章]

Molecular Definition of Breast Tumor Heterogeneity

2007.10.18
  Cancer Cell,V.11(3),2007, P259-273[Cell Press]  
     
[数据库推荐经典文章]

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult

2007.10.18
  Cell,V.126(4),2006,P663-676[Cell Press]  
     
[专家推荐热点文章]

The Metarhizium anisopliae Perilipin Homolog MPL1 Regulates Lipid Metabolism, Appressorial Turgor Pressure, and Virulence.

2007.9.13
  J Biol Chem. 2007;282(29):21110-5[JBC]  
     
[专家推荐热点文章]

Transient suppression of ligand-mediated activation of epidermal growth factor receptor by tumor necrosis factor-alpha through the TAK1-p38 signaling pathway.

2007.9.13
  J Biol Chem.2007;282(17):12698-706[JBC]  
     
[数据库推荐热点文章]

The potential of high-content high-throughput microscopy in drug discovery.

2007.9.13
  British J.Pharmacology.2007; 152(1): 62-71[Nature]  
     
[数据库推荐热点文章]

Endocrine regulation of energy metabolism by the skeleton.

2007.9.13
  Cell. 2007 ;130(3):456-69.[Cell Press]  
     
[数据库推荐热点文章]

Cellular senescence: when bad things happen to good cells.

2007.9.13
  Nat Rev Mol Cell Biol.2007;8(9):729-40[Nature]  
     
[数据库推荐热点文章]

IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1.

2007.9.13
  Eur J Immunol. 2007 ;37(7):1809-16[wiley]  
     
[数据库推荐经典文章]

Silicon-containing benzoxazines and their polymers: Copolymerization and copolymer properties

2007.9.13
  J. Polymer Sci Pt.A. 2006;45(6):1007-15[wiley]  
     
[数据库推荐经典文章]

The functional significance of the monomeric and trimeric states of the photosystem II light harvesting complexes.

2007.9.13
  Biochemistry.2004;43(2):501-9.[ACS]  
     
[数据库推荐经典文章]

Proteomic Analysis Reveals Novel Molecules Involved in Insulin Signaling Pathway

2007.9.13
  J.Proteome Res.2006;5(4):846-55[ACS]  
     
[数据库推荐经典文章]

Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain

2007.8.3
  Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8360-  
     
[数据库推荐热点文章]

A novel quantitative proteomics reagent based on soluble nanopolymers.

2007.8.3
  Chem Commun. 2007 Mar 28;(12):1251-3[RSC]  
     
[专家推荐热点文章]

Development of Dendritic-Cell Lineages

2007.8.3
  Immunity. 2007 26;741-750.[Cell Press]  
     
[数据库推荐热点文章]

Identification of Human MVB12 Proteins as ESCRT-I Subunits that Function in HIV Budding

2007.8.3
  Cell Host & Microbe.2007 2,41-53.[Cell Press]  
     
[数据库推荐经典文章]

Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing

2007.8.3
  Nature. 2003 24;422(6934):888-93[Nature]  
     
[数据库推荐经典文章]

Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42

2007.8.3
  Cell.2003 25;114(2):215-27.[Cell Press]  
     
[数据库推荐热点文章]

RXR Is an Essential Component of the Oncogenic PML/RARA Complex In Vivo.

2007.8.3
  Cancer Cell. 2007 Jul 10;12(1):23-35[Cell Press]  
     
[数据库推荐热点文章]

Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells.

2007.8.3
  Am J Physiol Endocrinol Metab.2007 292(3):756-64  
     
[数据库推荐经典文章]

Fedbatch Operation Using Clostridium acetobutylicum Suspension Culture as Biocatalyst for Enhancing Hydrogen Production

2007.8.3
  Biotechnol Prog. 2003 Mar-Apr;19(2):383-8 [ACS]  
     
[数据库推荐热点文章]

Protein Phosphorylation and Expression Profiling by Yin-Yang Multidimensional Liquid Chromatography (Yin-Yang MDLC) Mass Spectrometry

2007.8.3
  J Proteome Res. 2007 Jan;6(1):250-62.[ACS]  
     
[数据库推荐热点文章]

High-resolution profiling of histone methylations in the human genome.

2007.6.8
  Cell. 2007;129(4):823-37[CELL Press]  
     
[数据库推荐热点文章]

Error bars in experimental biology

2007.6.8
  Journal of Cell Biology,2007;177(1):7-11[JCB]  
     
[数据库推荐热点文章]

A Perivascular Niche for Brain Tumor Stem Cells

2007.6.8
  Cancer Cell. 2007;11(1):69-82.[CELL Press]  
     
[数据库推荐经典文章]

Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action

2007.6.8
  7:J Biol Chem. 2003 ;278(43):41779-88.[JBC]  
     
[专家推荐热点文章]

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.

2007.6.8
  Nature.2007;446(7137):758-64.[Nature]  
     
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Functional interaction between coactivators CBP/p300, PCAF, and transcription

2007.6.8
  J Biol Chem.2002;277(9):7029-36[JBC]  
     
[数据库推荐经典文章]

Mediators of vascular remodelling co-opted for sequential steps in lung

2007.6.8
  Nature.2007;446(7137):765-70.[Nature]  
     
[数据库推荐热点文章]

Behavioral phenotypes of Disc1 missense mutations in mice.

2007.6.8
  Neuron.2007;54(3):387-402 [CELL Press]  
     
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Synaptotagmin-1, -2, and -9: Ca2+ Sensors for Fast Release that Specify

2007.6.8
  Neuron.2007;54(4):567-81 [CELL Press]  
     
[数据库推荐经典文章]

Nerve growth cone guidance mediated by G protein-coupled receptors.

2007.6.8
  Nat Neurosci.2002,5(9):843-8.[Nature]  
     
 
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